Melanotan I 10mg
Research-grade Melanotan I 10mg. 99% purity, third-party tested with published COA.
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Compound Information
- Type
- Linear melanocortin receptor agonist (NDP-α-MSH)
- Molecular Formula
- C78H111N21O19
- Molecular Weight
- 1646.8 g/mol
- CAS Number
- 75921-69-6
- Purity
- 99%
- Sequence
- Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
- Also known as
- Afamelanotide, NDP-MSH
Reference chemistry (free base) from public chemical databases and peer-reviewed literature. For laboratory research identification only.
Research Use Only. This vial is bound for the lab bench — supplied for in-vitro scientific work exclusively, never for administration to any person or animal.
About Melanotan I (Afamelanotide)
Melanotan I and afamelanotide are the same molecule: a synthetic analog of alpha-melanocyte-stimulating hormone (alpha-MSH) with the acetylated, C-terminally amidated sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, molecular formula C78H111N21O19 and molecular weight approximately 1646.8 g/mol (CAS 75921-69-6, PubChem CID 16197727). It differs from native alpha-MSH at exactly two positions — methionine 4 replaced by norleucine, which blocks oxidation, and L-phenylalanine 7 replaced by its D-isomer, which resists proteolysis — which is why it appears in the literature as [Nle4, D-Phe7]-alpha-MSH (Sawyer et al., PNAS 1980, PMID 6777774).
A notation caution worth recording: the sequence cannot be written as a plain 13-letter string. Norleucine is non-proteinogenic and has no standard single-letter code, and the D-configuration at position 7 cannot be expressed in single-letter notation at all. Any listing showing a clean 13-letter sequence for this compound is inaccurate.
It is commonly described as MC1R-selective. That is not accurate. Afamelanotide is a full agonist at four melanocortin receptors — MC1, MC3, MC4 and MC5 — with roughly one to one and a half log units of preference for MC1 rather than exclusivity for it; it is not a recognised ligand at MC2, the ACTH receptor. Receptor affinities in the reference pharmacology databases are drawn from different assay types, so selectivity ratios computed across them are indicative rather than rigorous. Agonism at MC1, a Gs-coupled receptor, raises cyclic AMP and drives eumelanin synthesis in pigment-cell models independently of ultraviolet exposure. This product is supplied strictly for in vitro and laboratory research and is not for human or veterinary use.
Frequently Asked Questions
What is Melanotan 1?
Melanotan I is the research-era name for afamelanotide, a synthetic 13-amino-acid analog of alpha-melanocyte-stimulating hormone that acts as an agonist at melanocortin receptors. It differs from natural alpha-MSH at two positions, giving it greater resistance to oxidation and enzymatic breakdown. It is supplied here strictly for laboratory research use and is not for human or veterinary use.
Is Melanotan 1 the same as afamelanotide?
Yes — they are the same molecule. "Afamelanotide" is the international nonproprietary name and "Melanotan I" is the older research name. Databases resolve both, along with NDP-MSH and Melanotan-1, to a single compound record. Note that unqualified "melanotan" also refers to this compound rather than to Melanotan II, so the bare term is ambiguous in practice and worth avoiding.
What is the sequence of Melanotan 1?
It is the linear 13-residue peptide Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, acetylated at the N-terminus and amidated at the C-terminus, molecular formula C78H111N21O19 and molecular weight approximately 1646.8 g/mol. It cannot be written as a plain 13-letter string, because norleucine has no single-letter code and the D-configuration at position 7 cannot be expressed in that notation.
What is the difference between Melanotan 1 and Melanotan 2?
They are structurally different molecules. Melanotan I is a linear 13-residue peptide; Melanotan II is a smaller cyclic 7-residue peptide closed by a side-chain lactam bridge between positions 2 and 7. Both are non-selective full agonists across melanocortin receptors, so the common claim that one is MC1-selective and the other is not is unsupported by the receptor data. Both are supplied here for laboratory research use only.
Is Melanotan 1 selective for MC1R?
No, despite the frequency of that claim. It is a full agonist at MC1, MC3, MC4 and MC5, with roughly one to one and a half log units of preference for MC1 rather than exclusivity. It is not a recognised ligand at MC2, the ACTH receptor. Describing it as an MC1 receptor agonist is accurate; describing it as MC1-selective is not.
Is Melanotan 1 an approved drug?
The material supplied here is not. It is a research chemical intended for in vitro and laboratory use only, it is not a pharmaceutical product, and it is not for human or veterinary use.
Related Research Peptides
Research & References
Independent databases and peer-reviewed literature for Melanotan I. Provided for research reference only.
External resources are independent and not affiliated with or endorsed by PHIOGEN. Listed for laboratory research reference only.
